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Amlodipine-induced gingival overgrowth is generally reported at the dose of 10 mg/day within three months of drug initiation. Significant gingival overgrowth (SGO) is observed in 6.3% and 1.7% of people taking nifedipine and amlodipine, respectively, with a male preponderance. On palpation, the enlarged gingiva was firm, fibrotic, and nontender.Īmlodipine is a dihydropyridine calcium channel blocker with structural similarities to nifedipine, which is a common cause of gum hypertrophy. There was no history of similar symptoms in her family.Īs seen in Figure 1, intraoral examination revealed diffuse gingival enlargement involving marginal, attached, and interdental gingiva on both the buccal and lingual/palatal sides of the maxillary and mandibular anterior teeth, with mandibular gingiva exhibiting more severe changes. The patient had been taking 5 mg amlodipine of the same brand for three years for hypertension. She did not report having similar symptoms previously, and there was no past or current history of other drug intake. Her last menstrual period was two months back, and her cycles have been irregular, with bleeding lasting up to 10-12 days since the previous year.

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She also had mild bilateral pitting pedal edema, with no skin changes. The patient had pain in her teeth and gums and had a foul-smelling watery discharge from her gums moreover, food intake caused mild bleeding. The swelling was continuously present and slowly progressive. A 49-year-old perimenopausal woman presented to the outpatient clinic with a one-year history of swollen gums.

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